INDUCING UBIQUITINATION AND DEGRADATION OF TRXR1 PROTEIN BY LW-216 PROMOTES APOPTOSIS IN NON-SMALL CELL LUNG CANCER VIA TRIGGERING ROS PRODUCTION

Inducing ubiquitination and degradation of TrxR1 protein by LW-216 promotes apoptosis in non-small cell lung cancer via triggering ROS production

Thioredoxin reductases are frequently overexpressed in various Cardigans solid tumors as a protective mechanism against heightened oxidative stress.Inhibitors of this system, such as Auranofin, are effective in eradicating cancer cells.However, the clinical significance of thioredoxin reductase 1 (TrxR1) in lung cancer, as well as the potential for

read more

Japanese Guideline for Atopic Dermatitis 2014

Given the importance of appropriate diagnosis and appropriate assessment of cutaneous symptoms in treatment of atopic dermatitis, the basics of treatment in this guideline are composed of (1) investigation and coun- termeasures of causes and exacerbating factors, (2) correction of skin dysfunctions (skin care), and (3) pharmacotherapy, as three mai

read more


Prevalence of multidrug-resistant Vibrio species in fish in a reduction trial using lemon juice and sesame oil

Background: Because of its high nutritional value, excellent taste, and ease of digestion, fish is one of the most popular foods.However, it also serves as a vehicle for various pathogenic microorganisms, particularly Vibrio species, which pose a risk to public health.Aim: This study targeted studying the prevalence of multidrug resistant Vibrio sp

read more

The relationship between public debt and privatisation: the moderating roles of political ideology and electoral cycles

Using a sample of 25 European countries between 1995 and 2013, this study shows a bidirectional relationship between privatisations and public debt.Firstly, our findings suggest that governments with higher levels of debt tend to privatise state-owned enterprises (SOEs) to a greater extent than less-indebted governments.Subsequently, the Lighting r

read more